Santonio first appears in the U.S. registration record in 1966. Its popularity climbed over the following decades. In 2009, 47 babies received the name (ranked #2651). Today it sits well outside the top 1,000 (around #6905), with roughly 14 babies named Santonio each year. Santonio has been declining in recent years. In total, around 939 babies have been registered with this name since 1880.