The name Khadijatou is best understood as a variant, modern spelling, compound, or stylistic form connected to Khadija. The root name Khadija has origins in Arabic and is generally associated with the meaning premature child; historically associated with Khadijah, wife of the Prophet Muhammad. This gives Khadijatou a connection to the sound and symbolism of Khadija, while allowing for a more distinctive or contemporary spelling. Because Khadijatou itself may not have a separate ancient etymology, its meaning is most safely traced through the better-documented root name Khadija.

The root form of Khadijatou is Khadijatou — meaning "Pure" or "Trustworthy".

Khadijatou remains a beloved choice, ranking #6 in the US. Timeless appeal across cultures and generations.